Prevalence of Hypertension-Mediated Organ Damage Among Adults in Ethiopia: A Systematic Review and Meta-Analysis 2025
Meron Teklay Girmay1*, Temesgen Teklu Alemayehu1*, Dagem Gebremichael2*, Sherefedin Kedir Rashed3*, Tsion Tesfaye Degefu4 , Misrak Handamo4*, Haymanot Bekele Urga4 , Biruk Tadesse Officer1, Elias Gashaw Endegnanew5 , Gebremedhin Hailay Tsadik5 , Tsion Kebede Tegene6 , Amanuel Aklilu Alemu5 , Sumeya Hussen Idris7 , Elias Getahun Bayu5 and Tewodros Kassahun Tarekegn5
ABSTRACT
Introduction: evidences demonstrated that subclinical HMOD is strongly associated with adverse cardiovascular outcomes, including left ventricular hypertrophy, reduced kidney function, microalbuminuria, and increased arterial stiffness and mortality. Therefore, this study is aimed to estimate prevalence of hypertension-mediated organ damage in Ethiopian adults.
Methods and Material: PubMed, Scopus, web of science, and goggle scholar databases were used for this analysis. We assessed methodological quality using the Joanna Briggs Institute (JBI) critical appraisal checklist. An inverse variance-weighted random-effects model meta-analysis was performed to estimate the pooled prevalence with a 95% confidence interval (CI). The I2 test statistic was used to check between-study heterogeneity, and the Egger's regression statistical test was used to check publication bias. A p-value of less than 0.05 used to declare statistical significance.
Result: Ten studies with3751 participants were included in this analysis. Most of the included studies were cross-sectional studies with prevalence of hypertension-mediated organ damage among adults in Ethiopia were ranged from 14.2% to 92.1%. The pooled Prevalence of hypertension-mediated organ damage among adults in Ethiopia with a random-effects model was 37.2 2% (95% CI: 21.9-52.2).
Conclusion: This study showed that more than one-third of adults with hypertension in Ethiopia experience hypertension-mediated organ damage. Therefore, critical need of early diagnosis of hypertension, routine screening for target organ damage, and strengthened blood pressure management strategies is recommended.
