Ultraviolet Spectrophotometric Determination of Mefenamic Acid in Pharmaceutical Preparations and Environmental Wastewater Sample: Application to Content Uniformity
Nief Rahman Ahmed
ABSTRACT
A simple, precise, accurate, rapid, economical and sensitive Uv spectrophotometric method has been developed for the determination of mefenamic acid in pharmaceutical preparations and environmental wastewater samples, which shows maximum absorbance at280 nm in a solution of hydrochloric acid in methanol (1 in 1000). Beer's law was obeyed in the range of 2-25μg/ ml, with molar absorptivity of 0.79 ×104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.5%, and accuracy (average recovery %) was 100 ± 1.0. The method was successfully applied to the determination of mefenamic acid in some pharmaceutical formulations (tablets, capsules) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of mefenamic acid in true samples.
