Time to Change to Time: Single Amino Acid Resolution Anti-Tumor Platform Tag-TackTM is Standby
Jun Bai*, Yuan Zhang, Shiyuan Chen, Shangzhen Yang, Xincheng He, Shi Tang, Siming Chen, Xiangqian Quan, Haocong Liu, Jia Pei, Lanying Duan, Yang Sun, Wenxuan Xiao, Tong Li and Xuemin Xia
ABSTRACT
In order to shorten drug’s evolution time than personal cancer’s evolution time, a Tag-TackTM platform was designed and constructed to make introcytoplastic missense proteins to be druggable. We screened 8 human ScFVs specific targeting for 6 introcytoplastic missense proteins, and then cloned them into the platform to be Tag-TackerTM. 6 cell-lines harboring the former 6 introcytoplastic missense proteins were target killed by those 8 Tag-TackersTM, while no tagging protein cell-lines were alive. Thereby, a single amino acid resolution anti-tumor platform is standby!
