The Role of Monoclonal Antibodies in the Prevention of COVID-19 Infection and their Role in the Treatment of Patients with Complicated forms of the Infectious Disease (Literature Review)
Teplova NV, Evsikov EM*, Chobanyan MA1 and Vardanyan AG
ABSTRACT
Summary: The place of monoclonal body drugs in the prevention of covid-19 virus infection and their role in the treatment of patients with complicated forms of the infectious disease" The Relevance of the Problem: The global spread of coronavirus disease in many regions of the world has initiated the development and improvement of methods of immunological prevention and treatment of this pathology, contributed to the development of new technologies for the production of large amounts of monoclonal antibodies neutralizing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) and the creation of a number of effective
antiviral vaccines. Evaluation of their effectiveness in the prevention and treatment of this infectious disease has become the goal of a number of randomized international studies.
Purpose and Objectives: To determine the usefulness of monoclonal antibodies as a new class of therapeutic agents for the treatment of COVID-19 and predicted types of coronavirus infections.
The Content of the Work: The study of the immunological structure of the covid-19 virus and data from the compiled universal libraries of MATS obtained from healthy human donors made it possible in a short time to identify the molecular structures of the binding domain of the spike (S) protein receptor and use them to obtain antibodies that bind specifically to the angiotensin converting enzyme 2 cellular receptor and block the interaction of the virus with these protein structures in various cells and tissues of experimental animals. The effectiveness of these MATS and antibody cocktail has been confirmed in cellular and organ models of animals infected with SARS-CoV-2, both as a preventive and post-infectious treatment, and evidence of their effectiveness and safety has been obtained in a number of randomized clinical trials.
