Protocol Details and Outcome Analysis of 5 Years of Continuous Infertility Treatment in A Patient with Premature Ovarian Insufficiency/Failure and Complex Crohn’s Disease Utilizing Her Own Oocytes and Outcome of 3 Pregnancies
Priya Srivastava, Maya Srivastava, and Jerome H. Check*
ABSTRACT
Treatment options of POI patients wishing to increase the likelihood of conceiving with their own oocytes are limited. Current ASRM guidelines state no such interventions have demonstrated efficacy. Over the last three decades we have utilized techniques including ethinyl estradiol for follicular sensitization, that have resulted in successful pregnancy and live offspring in POI/POF and even menopausal patients. This case report is a final follow-up of a patient with Crohn’s disease and POI/POF from endometriosis first described by us in 2008. She successfully had two healthy daughters (one of whom is a co-author of this report) via IVF with her own oocytes and a gestational carrier. She recently transferred the final remaining frozen embryo to a different GC, who is 15 weeks pregnant with her son. Herein, using her original lab records, we detail each and every cycle, the interventions used and reasoning behind them, and the ultimate outcome of all transfers of all embryos. Our objectives are to increase awareness and understanding of these techniques and improve treatment options for POI/POF patients.
