Neonatal Seizures Secondary to Maternal Hypovitaminosis D: About Two Cases
Assem O, Lalaoui A, Bennaoui F*, Abi Alalaa K, El Idrissi Slitine N and Maoulainine FMR
ABSTRACT
Introduction: Maternal vitamin D deficiency is an etiology of neonatal hypocalcemia. We report two cases of cNeonatal convulsions secondary to maternal hypovitaminosis D.
Case Report 1: Newborn admitted on day 2 of life for afebrile neonatal convulsions. The clinical examination was normal. Biology showed normal blood sugar, hypocalcemia at54mg/l, normal parathyroid hormone and a low 25-hydroxyvitamin D dosage of 13.5 ng/l. Maternal assessment showed hypocalcemia at 62 mg/l and vitamin D deficiency at 4 ng/l. The diagnosis of neonatal deficiency hypocalcemia due to maternal hypovitaminosis D was retained. The evolution was favorable under correction of calcium and vitamin.
Case Report 2: Full-term newborn, delivery was vaginal with an APGAR score of 8/10. He was hospitalized for a weak sucking reflex, the infectious history was negative and the infectious assessment returned without abnormalities. At H12 the newborn presented generalized apyretic convulsions of the boxing and pedaling type, capillary blood sugar was 0.87 g/l and calcemia was low at 62 mg/l. The patient received oral calcium gluconate 10% at a dose of 4 ml/ kg/day combined with Alfacalcidol, which improved the clinical manifestations. The newborn’s phosphocalcic profile showed a vitamin D deficiency of 9.1 ng/ml and that of his mother showed hypocalcemia at 69 mg/l, hypovitaminosis D at 13 ng/ml and PTH at 57.9 pg/ml.
Conclusion: maternal vitamin D supplementation and sun exposure are essential to prevent neonatal hypocalcemia which can lead to serious neurological sequelae.
