Acute Anterior Uveitis Following Intravenous Zoledronic Acid Infusion: A Case Report
Leyla Eryiğit Eroğul
ABSTRACT
Background: Bisphosphonates are widely used in the treatment of osteoporosis and other metabolic bone diseases. Although these drugs are generally well tolerated, ocular inflammatory adverse effects such as conjunctivitis, episcleritis, scleritis, and uveitis have been reported.
Case Presentation: We report a case of acute anterior uveitis that developed shortly after intravenous zoledronic acid infusion. The patient presented with ocular pain, redness, photophobia, and decreased vision. Slit-lamp examination revealed conjunctival hyperemia and anterior chamber inflammation consistent with acute anterior uveitis. The patient was treated with topical corticosteroids and cycloplegic agents, resulting in rapid clinical improvement and complete resolution of symptoms.
Conclusion: Acute anterior uveitis is a rare but clinically significant adverse reaction associated with intravenous bisphosphonate therapy. Clinicians should
consider drug-induced uveitis in patients presenting with ocular symptoms following zoledronic acid infusion.
