A Discussion on Tumor Associated Neutrophils and Arginase-1 In Rectal Cancer. New Insights on the OR1 Scientific Experiment
Nicola Sarandria
ABSTRACT
Introduction: In this paper, a second set of results and graphs of a previously published scientific experiment will be revealed and discussed. Tumor Associated Neutrophils have been revealed to play an important role in regards of tumor progression and etiopathogenesis and several research teams around the world have been focusing on how to gather new intel to transfer this knowledge in a clinical setting in order to aid clinicians and patient management.
Methods: A total of 65 patients with histologically confirmed rectal adenocarcinoma were retrospectively included and stratified into four groups according to neoadjuvant treatment.
Conclusion: Patients with perineural invasion, patients who didn’t undergo any neoadj therapy with chemotherapy (so patients who underwent either CTRT or CT) have a statistically significant higher concentration of Arginase-1. Statistically significantly better DFS in patients whose tumor had no perineural invasion who underwent therapy (either CT or CTRT) vs those patients who had perineural invasion.
